Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-
TBK1/IKKε-IN-5
CAS: 1893397-65-3
Molecular Formula: C28H31N7O3
Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- - Names and Identifiers
| Name | TBK1/IKKε-IN-5 |
| Synonyms | Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- |
| CAS | 1893397-65-3 |
Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- - Physico-chemical Properties
| Molecular Formula | C28H31N7O3 |
| Molar Mass | 513.59 |
| Solubility | DMSO : 7.81 mg/mL (15.21 mM; Need ultrasonic) |
| Storage Condition | -20°C |
| Use | TBK1/IKKε-IN-5 (compound 1) is a double inhibitor of TBK1 and IKKε, and its IC50 values are 1 nM and 5.6 nM, respectively. |
Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.947 ml | 9.735 ml | 19.471 ml |
| 5 mM | 0.389 ml | 1.947 ml | 3.894 ml |
| 10 mM | 0.195 ml | 0.974 ml | 1.947 ml |
| 5 mM | 0.039 ml | 0.195 ml | 0.389 ml |
Last Update：2024-01-02 23:10:35
Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- - Reference Information
| biological activity | TBK1/ikkδ-in-5 (compound 1) is a TANK-binding kinase 1 (TBK1) the IC50 values for dual inhibitors of and IκB kinase-ε (IKK ε/IKK-i) are 1.0 nM and 5.6 nM for TBK1 and IKK ε, respectively. Inhibition of TBK1 /IKK ε enhances the response to PD-1 blockade, effectively predicting tumor response in vivo. |
| Target | Value |
| TBK1 (Cell-free assay) | 1.0 nM |
| IKKε (Cell-free assay) | 5.6 nM |
Last Update：2024-04-09 21:54:55
![Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-](http://res.chembk.com/assets/str/2d/1/18/1893397-65-3.png)
Supplier List
Spot supply
Product Name: TBK1/IKKε-IN-5 Visit Supplier Webpage Request for quotationCAS: 1893397-65-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: TBK1/IKKε-IN-5 Visit Supplier Webpage Request for quotationCAS: 1893397-65-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History